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Rabbit Anti-AChR alpha1 Polyclonal Antibody

Cat NoBSPA-0536
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationWB; ELISA
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsCHRNA1;ACHRA;CHNRA;Acetylcholine receptor subunit alpha
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundAChRα1 Antibody is a high quality monoclonal AChR alpha 1 antibody suitable for the detection of the AChR alpha 1 protein of mouse, rat, human, bovine and Torpedo origin. AChRα1 Antibody is available as both the non-conjugated anti-AChR alpha 1 antibody form, as well as multiple conjugated forms of anti-AChR alpha 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor?conjugates. Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChRα1, also known as ACHRD, CHRNA, CMS2A, FCCMS, SCCMS or CHRNA1, is a 482 amino acid multi-pass membrane protein that exists as two alternatively spliced isoforms, which are expressed in different tissues. Isoform 1 is only expressed in skeletal muscle whereas isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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