中文English Call: 400-669-8850 | E-mail: info@biotyscience.com

修饰性抗体

当前位置:首页 >>产品中心 >>抗体产品 >>一抗 >>修饰性抗体

Content

Contact us

Biotyscience Inc

Tel 400-669-8850

E-mail info@biotyscience.com

QQ  499854788

       82458988


Rabbit anti-Human Phospho-ULK1-S757 Polyclonal Antibody

Cat NoBPA-16904
Conjugate
TypePhosphorylated Antibody
SourceRabbit
Size50 uL
ApplicationWB
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS with 0.02% sodium azide,50% glycerol,pH7.3.
SpeciesHuman
StorageStore at -20℃. Avoid freeze / thaw cycles.
SynonymsULK1;ATG1;ATG1A;UNC51;Unc51.1;hATG1;ULk1
PurificationAffinity purification
MolecularWeight145KDa
Description
BackgroundSerine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
咨询热线:
客服:400-669-8850 产品:177-3110-0244 服务:136-8125-6816
在线客服:
产品咨询-1点击这里给我发消息QQ交谈
服务咨询-2点击这里给我发消息QQ交谈
微信二维码:
公司官网: www.biotyscience.com