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Cat No | BPA-17243 |
Conjugate | |
Type | Phosphorylated Antibody |
Source | Rabbit |
Size | 50 uL |
Application | WB |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS with 0.02% sodium azide,50% glycerol,pH7.3. |
Species | Human |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Synonyms | RPS6KA5;MSK1;MSPK1;RLPK |
Purification | Affinity purification |
MolecularWeight | 90kDa |
Description | |
Background | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli (PubMed:11909979). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924). In skeletal myoblasts is required for phosphorylation of RELA at Ser-276 during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the Ser-727 phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at Ser-191 and Ser-216, and thereby regulates its ability to stimulate transcription (PubMed:12569367). Directly represses transcription via phosphorylation of Ser-1 of histone H2A (PubMed:15010469). Phosphorylates Ser-10 of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. |