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Cat No | BIOC1139 |
Conjugate | |
Type | Carrier Material |
Source | N/A |
Size | 1 g |
Application | |
Format | Powder |
Buffer | 溶于DMSO,DMF,DCM,溶于水。 |
Storage | Store at 2-8℃. Keep away from light. |
Synonyms | Mal-PEG-NHS;马来酰亚胺-聚乙二醇-活性脂 |
Purification | ≥95% |
MolecularWeight | 2000/3400/5000 |
Description | |
Background | MAL-PEG-NHS is a heterofunctional PEG derivative with maleimide and NHS ester at both ends of the molecular chain. It is a useful cross-linker with a PEG spacer group. At neutral pH, maleimide can react quickly with sulfhydryl/sulfhydryl groups to form stable sulfide bonds. Maleimide contains a reactive C = C double bond and is sensitive to light or oxygen. NHS is a white crystalline substance that can be used as a pharmaceutical intermediate for the production of Semi-synthetic Kanamycin or as a solid-phase synthetic linker for polypeptides. NHS esters react with deprotonated primary amines, therefore, the reaction requires neutral to basic pH values to proceed. MAL-PEG-NHS can be easily incorporated into liposomes and other nanoparticles through the NHS-amine reaction. |