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Cat No | BIOS-1795F |
Conjugate | |
Type | 流式抗体 |
Clone | RMT3-23 |
Source | Anti-Mouse |
Tag | PE |
Size | 1 mg |
Application | FCM |
Format | Liquid |
Purity | >90% |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS; pH 7.4. |
Storage | Store at -20 degree for long term. |
Synonyms | TIM3;TIMD3;HAVcr-2;TIMD-3 |
Purification | SDS-PAGE |
MolecularWeight | |
Description | |
Background | CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. |