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Mouse Anti-Foxp3 Antibody(Clone 3G3), FITC

Cat NoBIOS-2637F
Conjugate
Type流式抗体
Clone3G3
SourceMouse
TagFITC
Size1 mg
ApplicationFCM
FormatLiquid
Purity>90%
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS; pH 7.4.
StorageStore at -20 degree for long term.
SynonymsForkhead box protein P3;IPEX;JM2;Foxp3
PurificationSDS-PAGE
MolecularWeight
Description
BackgroundFOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25-聽cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 未2) lacking exon 2.
We can provide a variety of products such as diagnostic proteins; target proteins; cytokines; etc.
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