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Recombinant Human Factor VIII protein,His

Cat NoADMD-042
Conjugate
Type重组蛋白
SourceE. coli
TagHis
Size50ug
ApplicationImmunology
FormatLiquid
Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration>0.05 g/L as determined by microplate BCA method
Buffer50 mM Tris-HCl, pH 8.0, 8 M urea
SpeciesHuman
StorageStore at -80 °C.
SynonymsAHF;DXS1253E;F8B;F8C;FVIII;HEMA
PurificationProtein A
NoteFor testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
MolecularWeight24.5 kDa
Description
BackgroundThis gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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