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Cat No | ADMD-050 |
Conjugate | |
Type | 重组蛋白 |
Source | HEK293 |
Tag | Fc |
Size | 1mg |
Application | Immunology |
Format | Liquid |
Purity | >90 %, SDS-PAGE |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS |
Species | Human |
Storage | Store at -20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | BAFF, BLYS, CD257, DTL, TALL1, TALL-1, THANK, TNFSF13B, TNFSF20, ZTNF4 |
Purification | Protein A/G |
Note | For research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. |
MolecularWeight | 43 kDa |
Description | |
Background | TNFSF13B, also known as BAFF, BLYS, TALL1, TNFSF20, ZTNF4 and CD257, is a cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. This cytokine is expressed in B lineage cells, and acts as a potent B cell activator. The BAFF system promotes B cell survival and differentiation and plays a prominent role in the pathogenesis of autoimmune diseases. It has been shown that BAFF inhibitors are in clinical trials for systemic lupus erythematosus with significant efficacy. |