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Recombinant Human ICOS protein,Fc,Myc,His

Cat NoADMD-070
Conjugate
Type重组蛋白
SourceHEK293
TagFc,Myc,His
Size1mg
ApplicationImmunology
FormatLiquid
Purity>90 %, SDS-PAGE
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS
SpeciesHuman
StorageStore at -20 degree. Avoid repeated freeze/thaw cycles.
SynonymsAILIM, CD278, CVID1, ICOS, Inducible T cell costimulator
PurificationProtein A/G
NoteFor research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
MolecularWeight42.1 kDa
Description
BackgroundInducible T-cell costimulator (ICOS) is an activation-dependent, T cell-specific cell surface molecule related to CD28 and CTLA-4. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. ICOS has to be de novo induced on the T-cell surface, does not upregulate the production of interleukin-2, but superinduces the synthesis of interleukin-10, a B-cell-differentiation factor. ICOS activated T-cells, Highly expressed on tonsillar T-cells, are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. It is expressed at lower levels in thymus, lung, lymph node, and peripheral blood leukocytes. It is also expressed in the medulla of the fetal and newborn thymus.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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