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Recombinant Human TL1A/TNFSF15 protein,His

Cat NoADMD-084
Conjugate
Type重组蛋白
SourceHEK293
TagHis
Size1mg
ApplicationImmunology
FormatLiquid
Purity>95?%, SDS-PAGE
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS
SpeciesHuman
StorageStore at -20 degree. Avoid repeated freeze/thaw cycles.
SynonymsTL1, TL1A, TNFSF15, VEGI, VEGI192A
PurificationProtein A/G
NoteFor research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
MolecularWeight21.5 kDa
Description
BackgroundTumor necrosis factor ligand superfamily member 15 (TNFSF15) is also named as TL1 and VEGI. And it belongs to the tumor necrosis factor family. It is a receptor for TNFRSF25 and TNFRSF6B. VEGI induced degradation of IκB alpha, and nuclear translocation of p65 subunit of NFκB by activating NFκB. TL1A mediates activation and apoptosis of NFκB in DR3-expressing cell lines. Overexpression by cancer cells of a secretable VEGI fusion protein resulted in abrogation of xenograft tumor progression. The isoforms show endothelial cell-specific expression and are generated from a 17 kb human gene by alternative splicing. In addition, VEGI can inhibit vascular endothelial growth and angiogenesis (in vitro).
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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