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Recombinant Mouse IL-6R alpha protein,His

Cat NoADMD-101
Conjugate
Type重组蛋白
SourceHEK293
TagHis
Size1mg
ApplicationImmunology
FormatLiquid
Purity>95 %, SDS-PAGE
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS
SpeciesMouse
StorageStore at -20 degree. Avoid repeated freeze/thaw cycles.
SynonymsCD126, gp80, IL6R, IL-6R alpha, IL-6RA, IL6RQ
PurificationProtein A/G
NoteFor research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals.
MolecularWeight38.8 kDa
Description
BackgroundInterleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge. IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL-6R alpha, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL-6R alpha, the complex of IL-6 and IL-6R alpha associates with gp130, thus activating the receptor. Expression of gp130 is found in almost all organs while expression of IL-6R alpha is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells). Soluble form of IL-6R alpha has been found in human serum and urine.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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