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Cat No | BIOP1875 |
Conjugate | |
Type | Fc-Fc受体 |
Source | HEK293 |
Tag | His |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS, pH 7.4. |
Species | Mouse |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Low affinity immunoglobulin gamma Fc region receptor II;Fc gamma receptor IIB;Fc-gammaRII;Fc-gamma-RIIB;FcRII;IgG Fc receptor II beta;Lymphocyte antigen 17;Ly-17;CD32;Fcgr2;Fcgr2b;Ly-17 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 30-210 |
Background | Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane proteinand contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells andmyeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in somecircumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cellactivation. CD32B may also be a target formonoclonal antibody therapy for malignancies. |