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Recombinant Mouse IL-4RA/IL-4 R alpha Protein(aa 26-233), Fc

Cat NoBIOP2115
Conjugate
Type白介素
SourceHEK293
TagFc
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS,pH 7.4.
SpeciesMouse
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsInterleukin-4 receptor subunit alpha;IL-4R-alpha;CD124;IL4-BP;Soluble IL-4R-alpha
Purification> 90% by SDS-PAGE.
MolecularWeight
Descriptionaa 26-233
BackgroundInterleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to thetype I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions asreceptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgEproduction and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RAcan signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed byinitial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immunecells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R canalso interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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