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Recombinant Human 4-1BB Ligand/TNFSF9 Protein(aa 71-254), His

Cat NoBIOP2210
Conjugate
Type免疫检查点
SourceE. coli
TagHis
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 50mM Tris, 150mM NaCl, pH 8.0.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms4-1BB-L;CD137L;TNLG5A
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 71-254
BackgroundThe protein is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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