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Cat No | BIOP2581 |
Conjugate | |
Type | 其他蛋白 |
Source | E. coli |
Tag | His |
Size | 10 ug |
Application | Immunogen |
Format | Lyophilized |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in 50mM TrisHCl,pH 8.0. |
Species | Human |
Storage | Store at –20 degree. Avoid repeated freeze/thaw cycles. |
Synonyms | Estrogen Receptor Beta;ER-Beta;Nuclear Receptor Subfamily 3 Group A Member 2;ESR2;ESTRB;NR3A2 |
Purification | > 95% by SDS-PAGE. |
MolecularWeight | |
Description | aa 1-323 |
Background | Estrogen Receptor Beta (ESR2) is a nuclear protein that belongs to the nuclear hormone receptor family of NR3subfamily. It contains one nuclear receptor DNA-binding domain and is expressed in many tissues at a lowerlevel. ESR2 is a nuclear hormone receptor. It binds estrogens with an affinity similar to that of ESR1 andactivates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependentmanner. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while inthe presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature ismore gradual. |