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Recombinant Human IL-12RB1/IL-12 R beta 1/IL-12RB Protein(aa 24-540), Fc

Cat NoBIOP2911
Conjugate
Type生物标志物
SourceHEK293
TagFc
Size10 ug
ApplicationImmunogen
FormatLyophilized
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS, pH 7.4.
SpeciesHuman
StorageStore at –20 degree. Avoid repeated freeze/thaw cycles.
SynonymsCD212;IL12RB1;CD212;CD212 antigen;IL-12 receptor beta component;IL-12 receptor subunitbeta-1;IL12R;IL-12R subunit beta-1;IL12RB;IL-12RB1;IL-12R-BETA1;IL-12R-beta-1;interleukin-12 receptor beta-1 chain;interleukin-12 receptor subunit beta-1
Purification> 95% by SDS-PAGE.
MolecularWeight
Descriptionaa 24-540
BackgroundInterleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to thehemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers, which areable to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunitsdesignated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit, IL-12p35 is mainlyconnecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell.IL12RB1, to the contrary, is also part of the IL23R, where it interacts with the p40 subunit of IL23. IL12RB1 isexpressed in activated T cells, NK cells and B cells.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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