Recombinant Human IFNAR2/IFNARB Protein, Fc-His-重组蛋白-北京百欧泰生物科技有限公司

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抗体产品
- 一抗
  - --|--|流式抗体
  - --|--|单克隆抗体
  - --|--|重组兔单抗
  - --|--|多克隆抗体
  - --|--|小分子抗原抗体
  - --|--|抗体对
  - --|--|标签抗体
  - --|--|修饰性抗体
  - --|--|其他抗体
- 二抗
- 试剂盒
  - --|--|标记试剂盒
  - --|--|其他试剂盒
  - --|--|标记染料
蛋白产品
生物材料
- 金属纳米材料
  - --|--|金纳米颗粒
  - --|--|金纳米棒
  - --|--|银纳米颗粒
  - --|--|金纳米海胆
  - --|--|碳纳米颗粒
  - --|--|特殊形状纳米颗粒
- 磁性微球
  - --|--|PS Magnetic Particles
  - --|--|Silica Magnetic Particles
  - --|--|Fe3O4 Magnetic Particles
  - --|--|Functionalized Magnetic Particles
  - --|--|Magnetic Particles Conjugates
  - --|--|Fe2O3 Magnetic Particles
  - --|--|UF Magnetic Particles
  - --|--|Conjugation Kit
  - --|--|Other Magnetic Particles
  - --|--|磁力架
- 单分散微球
  - --|--|聚苯乙烯微球
  - --|--|二氧化硅微球
  - --|--|PMMA 微球
  - --|--|PET 微球
  - --|--|PVA 微球
  - --|--|PVC 微球
  - --|--|DVB 微球
  - --|--|PP 微球
  - --|--|PE 微球
  - --|--|GMA 微球
  - --|--|PLA微球
  - --|--|PLGA微球
  - --|--|PLLA微球
  - --|--|PDLA微球
- 其他材料
  - --|--|上转换纳米颗粒
  - --|--|量子点
  - --|--|荧光微球
  - --|--|色谱填料
热销产品
- 猴痘相关产品
- 新冠相关产品
- 外泌体相关产品
- 常用试剂
  - --|--|转染试剂
  - --|--|ELISA-FCM试剂
  - --|--|WB试剂
  - --|--|IHC-ICC-IF试剂
  - --|--|载体材料

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Recombinant Human IFNAR2/IFNARB Protein, Fc-His

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Cat No	BIOP3452
Conjugate
Type	细胞因子
Source	HEK293
Tag	Fc-His
Size	20 ug
Application	Immunogen
Format	Lyophilized
Concentration	Please refer to the vial lable for the specific concentration.
Buffer	Supplied in PBS, pH 7.4.
Species	Human
Storage	Store at –20 degree. Avoid repeated freeze/thaw cycles.
Synonyms	IFNAR2;IFNARB;IFNABR;IFN-R-2
Purification	> 95% by SDS-PAGE.
MolecularWeight
Description
Background	Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family.Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Initial cell-surface IFNAR2 expression at diagnosis assessed by flow cytometry was widely distributed but showed overall significantly higher expression in CML patients when compared with normal controls. In 15 fresh patients who subsequently received IFNα therapy, IFNAR2 expression at diagnosis was significantly higher in cytogenetic good responders than in poor responders. Down-regulation of IFNAR2 expression during IFNα therapy was observed only in good responders but not in poor responders. The encoded protein also functions as an antiviral factor. IFNAR2 may associate with IFNAR1 to form the type I interferon receptor. This protein serves as a receptor for interferons alpha and beta. IFNAR2 is also involved in IFN-mediated STAT1, STAT2, and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Following binding of IFNα2, IFNAR2 is internalized, but, instead of being routed towards degradation as it is when complexed to IFNβ, it recycles back to the cell surface.

We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.

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Recombinant Human IFNAR2/IFNARB Protein, Fc-His