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Axl, His

Cat NoBSA-0072A
Conjugate
Type重组蛋白
SourceMammalian cell
TagHis
Size1 mg
ApplicationImmunogen; Calibrator; Standard
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in 1×PBS, pH 7. 4.
StorageStore at -20 degree. Avoid repeated freeze/thaw cycles.
Synonyms酪氨酸蛋白激酶受体;AXL;Axl;Ark;Ufo;Tyro-7
Purification> 90% by SDS-PAGE
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
Background酪氨酸蛋白激酶受体(Axl)又名Ark、Ufo和Tyro-7, 是一种细胞表面的跨膜受体, Axl的相对分子量约为140KD. 由分布在44kb区城的20个外显子编码, 基因位于第19号染色体. 分子分为胞外区、胞内区和跨脯区3部分:其中胞外区包括2个免疫球蛋白样区(lg)和2个纤连蛋白Ⅲ(FNⅢ)样区. Ig样区是配体结合区, FNⅢ区在AxJ与配体结合的过程中起调节作用. Axl的胞外区与神经细胞贴附分子结构相似; 且胞内区有酪氨酸激醇活性, 所以Axl可促进细胞粘附和增殖. Axl与配体生长停滞特异性基因6(Gas6)蛋白结合, 发生磷酸化, 磷酸化位点与相应蛋白结合, 激活下游信号转导通路, 进而发挥促进细胞增殖、抗凋亡、迁移、侵袭等生物学功能.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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