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Cat No | BSA-1033 |
Conjugate | |
Type | 重组蛋白 |
Source | HEK293 |
Tag | Fc |
Size | 1mg |
Application | Immunology |
Purity | ≥95%, SDS-PAGE |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS with 6% Mannitol, pH7.4. |
Storage | Store at -20 degree for long time. Avoid repeated freeze/thaw cycles. |
Synonyms | AITR;GITR;TNFRSF18;CD357 |
Purification | Chromatography |
MolecularWeight | 41.5kD |
Description | 内毒素<0.1EU/ug |
Background | GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway. |