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Rabbit Anti-NLRP3 Polyclonal Antibody

Cat NoBSPA-2352
Conjugate
TypePolyclonal Antibody
SourceRabbit
Size1 mg
ApplicationELISA; IHC
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS.
SpeciesHuman
StorageStore at -20 degree. Avoid repeted freeze/thaw cycl.
SynonymsNLRP3;NLR family, pyrin domain containing 3;AII;AVP;FCU;MWS;FCAS;CIAS1;FCAS1;NALP3
Purification
NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MolecularWeight
Description
BackgroundThis gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome , Muckle-Wells syndrome , chronic infantile neurological cutaneous and articular syndrome, and neonatal-onset multisystem inflammatory disease . Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5 UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5 UTR splice patterns are biologically valid.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.
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